In a thread about the value (or lack of value) of "pressure points" in martial arts (Systema), Charles wrote as below:

From my experience as a lawyer, the most permanently damaging or fatal, situation in real life comes not as a result of any pressure point or exotic manuever.
The worst nightmare is simply is a bouncer/drunk/nitwit punching someone who is rendered unconscious and then falls, striking his head on the pavement. I have had 3 clients victimized in that fashion with catastrophic results. And another 2 beaten by police with flashlights and then falling unconscious and striking the back of their head on the ground.
When the victim does not die outright, they lead the rest of their a shell of their former selves.
In my opinion, study this art, or any other, for purposes of self-improvement and union of mind and body. Prisons and jails are full of dangerous men and boys. I doubt if any of them knew pressure points, but they sure knew how to ruin or take the lives of others.
Oh, if it matters 5of the 6 above did not start a fight and in fact did not even know they know their attackers etc. And yes, not one of them has any memory of what happened, bystanders witnesses and videocams filled in the story. I will not discuss these cases more than I have, except to warn you that there are gangs or loosely associated young men who simply enjoy hurting people. Perhaps they did not intend the grievous results, but they intentionally threw savage, full body weight punches. Punches you dont want to even watch on tape.